I've struggled with my weight for years. For the better part of my twenties I dealt with an eating disorder. I was down to 112lbs (50kg) and a US size 2 pants. And I loved it. I could wear all of the cute clothes that I was too big for in high school, and I felt really good about myself.
Then I broke my ankle. Sometimes I think that is directly due to the fact that I was extremely malnourished. My bone shattered like a lightbulb and had to be surgically reconstructed. It was baaaaaad. My boyfriend swears it's because I stepped into an 18 inch (45cm) deep hole while walking full speed ahead. It was definitely a combo of both.